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Senior Principal Scientist Machine Learning / Protein Design

Recruiter
Bristol Myers Squibb
Location
San Diego
Salary
Competitive
Closing date
5 Jan 2023

View more

Employer Sector
Scientific
Contract Type
Permanent
Hours
Full Time
Travel
None
Job Type
Analytics, Machine Learning

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

Job Description

We are seeking a collaborative machine learning scientist with expertise in protein structure prediction and design to join the Predictive Sciences team. You will be responsible for the research and development of innovative computational approaches and workflows to design and optimize proteins. This role provides the opportunity to leverage large-scale proprietary datasets and work with subject matter experts on cross-functional teams to solve challenging problems in how we discover and engineer the next generation of biotherapeutics.

Responsibilities

  • Pioneer machine learning research into antibody-antigen interaction modeling and design using internal and external datasets.
  • Partner with project teams to advance sequence- and structure-based antibody discovery and design.
  • Develop and implement computational approaches and prediction algorithms that can map linear and three-dimensional epitopes, optimize binding scaffolds and library design to guide screening, identify and mature the affinity of antibody hits, and assess potential liabilities and optimal development options.
  • Communicate findings and recommend follow-up actions in multiple settings such as 1:1, seminars, group, and project meetings.

Basic Qualifications

  • Bachelor's Degree in structural bioinformatics, computer science, engineering, statistics, or similar and 10+ years of academic / industry experience

  • OR Master's Degree in structural bioinformatics, computer science, engineering, statistics, or similar and 8+ years of academic / industry experience

Preferred Qualifications

  • Ph.D. in structural bioinformatics, computer science, engineering, statistics, or similar with 8+ years of relevant experience.
  • Deep expertise in modern neural network architectures including transformers, autoencoders, GANs, attention models. Familiarity with Tensorflow/JAX and its ecosystem, as well as other platforms such as scikit, and design of effective experiments and metrics.
  • Experience with state-of-the-art machine learning approaches applied to biological sequence data (RNA, DNA, proteins) in the molecular and cell biology domains.
  • Proven track record of contributing to and helping advance multi-disciplinary team projects.
  • Expertise with a high-level programming language such as R or Python for sophisticated data analysis and reproducible research practices.
  • Scientific curiosity with an ability to identify questions machine learning approaches can address, and the skills to develop solutions both independently and collaboratively.
  • Excellent problem-solving skills and teamwork.
  • Strong communication, data presentation, and visualization skills.
  • Knowledge in biochemistry or protein engineering is a plus.

The starting compensation for this job is a range from $159,000-$220,000, plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and the where the job is performed.

Final individual compensation will be decided based on demonstrated experience.

For more on benefits, please visit our .

Eligibility for specific benefits listed on our BMS Careers site may vary based on the job and location.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

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